Miwa, Gerald: search on Z-Library

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1

Bioactivation of Drugs: Risk and Drug Design

Walsh, John S., Miwa, Gerald T.

Journal:

Annual Review of Pharmacology

Year:

2011

Language:

english

File:

PDF, 2.25 MB

english, 2011

2

Strategy of Utilizing In Vitro and In Vivo ADME Tools for Lead Optimization and Drug Candidate Selection

Balani, Suresh, Miwa, Gerald, Gan, Liang-Shang, Wu, Jing-Tao, Lee, Frank

Journal:

Current Topics in Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 89 KB

english, 2005

3

Comparison of Species Differences of P-Glycoproteins in Beagle Dog, Rhesus Monkey, and Human Using ATPase Activity Assays

Xia, Cindy Q., Xiao, Guangqing, Liu, Ning, Pimprale, Satish, Fox, Lisa, Patten, Chris J., Crespi, Charles L., Miwa, Gerald, Gan, Liang-Shang

Journal:

Molecular Pharmaceutics

Year:

2006

Language:

english

File:

PDF, 245 KB

english, 2006

4

The Conduct of In Vitro and In Vivo Drug-Drug Interaction Studies: A PhRMA Perspective

Bjornsson, Thorir D., Callaghan, John T., Einolf, Heidi J., Fischer, Volker, Gan, Lawrence, Grimm, Scott, Kao, John, King, S. Peter, Miwa, Gerald, Ni, Lan, Kumar, Gondi, McLeod, James, Obach, Scott R.

Journal:

Journal of Clinical Pharmacology

Year:

2003

Language:

english

File:

PDF, 192 KB

english, 2003

5

Studies with nitrogen-containing steroids and freshly isolated rat hepatocytes: Role of cytochrome P-450 in detoxication

Gregory L. Kedderis, Lois S. Argenbright, Gerald T. Miwa

Journal:

Toxicology and Applied Pharmacology

Year:

1988

Language:

english

File:

PDF, 870 KB

english, 1988

6

Drug safety evaluation through biomarker analysis—A toxicity study in the cynomolgus monkey using an antibody-cytotoxic conjugate against ovarian cancer

Frank Y. Hsieh, Elizabeth Tengstrand, Ju-Whei Lee, Lily Y. Li, Lee Silverman, Bill Riordan, Gerald Miwa, Mark Milton, Carl Alden, Frank Lee

Journal:

Toxicology and Applied Pharmacology

Year:

2007

Language:

english

File:

PDF, 601 KB

english, 2007

7

Microsomes, Drug Oxidations and Chemical Carcinogenesis || KINETIC ISOTOPE EFFECTS IN CYTOCHROME P-450-CATALYZED OXIDATION REACTIONS. I. SUBSTRATE - CYTOCHROME P-450 INTERACTIONS

Miwa, Gerald T.

Year:

1980

File:

PDF, 261 KB

1980

8

Application of quantitative GC-mass spectrometry to study of pharmacokinetics of amphetamine and phentermine

Arthur K. Cho, Barbara J. Hodshon, Björn Lindeke, Gerald T. Miwa

Journal:

Journal of Pharmaceutical Sciences

Year:

1973

Language:

english

File:

PDF, 416 KB

english, 1973

9

Elucidation of potential bortezomib response markers in mutliple myeloma patients

Frank Y. Hsieh, Elizabeth Tengstrand, Teresa M. Pekol, Roberto Guerciolini, Gerald Miwa

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2009

Language:

english

File:

PDF, 1.01 MB

english, 2009

10

The role of metabolism and covalent binding in the cytotoxicity of a nitrogen-containing steroid toward rat hepatocytes

Gregory L. Kedderis, Lois S. Argenbright, Gerald T. Miwa

Journal:

Toxicology and Applied Pharmacology

Year:

1990

Language:

english

File:

PDF, 518 KB

english, 1990

11

Selective inactivation of cytochrome P-450 isozymes by suicide substrates

Paul R.Ortiz De Montellano, Bruce A. Mico, James M. Mathews, Kent L. Kunze, Gerald T. Miwa, Anthony Y.H. Lu

Journal:

Archives of Biochemistry and Biophysics

Year:

1981

Language:

english

File:

PDF, 1.05 MB

english, 1981

12

The metabolic activation of nitroheterocyclic therapeutic agents

Kedderis, Gregory L., Miwa, Gerald T.

Journal:

Drug Metabolism Reviews

Year:

1988

Language:

english

File:

PDF, 1.47 MB

english, 1988

13

Mechanism of metabolic activation of ronidazole, a 5-nitroimidazole

LU, ANTHONY Y. H., WISLOCKI, PETER G., BAGAN, EDWARD S., WANG, REGINA W., WALSH, JOHN S., MIWA, GERALD T.

Journal:

Biochemical Society Transactions

Year:

1984

Language:

english

File:

PDF, 343 KB

english, 1984

14

Microsomes, Drug Oxidations and Chemical Carcinogenesis || KINETIC ISOTOPE EFFECTS IN CYTOCHROME P-450-CATALYZED OXIDATION REACTIONS. I. SUBSTRATE - CYTOCHROME P-450 INTERACTIONS

Miwa, Gerald T.

Year:

1980

Language:

english

File:

PDF, 261 KB

english, 1980

15

The synthesis of 14C, 3H and 2H labeled 7-ethoxycoumarins

John S. Walsh, Holly E. Mertel, Gerald T. Miwa

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1983

Language:

english

File:

PDF, 266 KB

english, 1983

16

Production of hydroxyl radicals and their role in the oxidation of ethanol by a reconstituted microsomal system containing cytochrome P-450 purified from phenobarbital-treated rats

Arthur I. Cederbaum, Gerald Miwa, Gerald Cohen, Anthony Y.H. Lu

Journal:

Biochemical and Biophysical Research Communications

Year:

1979

Language:

english

File:

PDF, 402 KB

english, 1979

17

Covalent interaction of 5-nitroimidazoles with DNA and protein in vitro: mechanism of reductive activation

Kedderis, Gregory L., Argenbright, Lois S., Miwa, Gerald T.

Journal:

Chemical Research in Toxicology

Year:

1989

Language:

english

File:

PDF, 503 KB

english, 1989

18

Kinetic isotope effects and ‘metabolic switching’ in cytochrome P450-catalyzed reactions

Gerald T. Miwa, Anthony Y. H. Lu

Journal:

Year:

1987

Language:

english

File:

PDF, 633 KB

english, 1987

19

Aldrin Epoxidation Catalyzed by Purified Rat-Liver Cytochromes P-450 and P-448 High Selectivity for Cytochrome P-450

Thomas WOLFF, Helmut GREIM, Mou-Tuan HUANG, Gerald T. MIWA, Anthony Y. H. LU

Journal:

Year:

1980

Language:

english

File:

PDF, 617 KB

english, 1980

20

The association of cytochrome P-450 and NADPH-cytochrome P-450 reductase in phospholipid membranes

Gerald T. Miwa, Anthony Y.H. Lu

Journal:

Archives of Biochemistry and Biophysics

Year:

1984

Language:

english

File:

PDF, 541 KB

english, 1984

21

Tissue Drug Residues and their Toxicological Significance

Lu, Anthony Y. H., Wislocki, Peter G., Chiu, Shuet-Hing Lee, Miwa, Gerald T.

Journal:

Drug Metabolism Reviews

Year:

1987

Language:

english

File:

PDF, 753 KB

english, 1987

22

The metabolic activation of ronidazole [(1-methyl-5-nitroimidazole-2-yl)-methyl carbamate] to reactive metabolites by mammalian, cecal bacterial and T. foetus enzymes

Gerald T. Miwa, Regina Wang, Raul Alvaro, John S. Walsh, Anthony Y.H. Lu

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 504 KB

english, 1986

23

Induction of rat liver cytosol methyl red azo-reductase by 3-methylcholanthrene assayed by a sensitive fluorometric method

Mou-Tuan Huang, Gerald T. Miwa, Anthony Y.H. Lu

Journal:

Biochemical and Biophysical Research Communications

Year:

1978

Language:

english

File:

PDF, 373 KB

english, 1978

24

Drug residue formation from ronidazole, a 5-nitroimidazole. VIII. Identification of the 2-methylene position as a site of protein alkylation

Raul F. Alvaro, Peter G. Wislocki, Gerald T. Miwa, Anthony Y.H. Lu

Journal:

Chemico-Biological Interactions

Year:

1992

Language:

english

File:

PDF, 533 KB

english, 1992

25

Studies on the stimulation of cytochrome P-450-dependent monooxygenase activity by dilauroylphosphatidylcholine

Gerald T. Miwa, Anthony Y.H. Lu

Journal:

Archives of Biochemistry and Biophysics

Year:

1981

Language:

english

File:

PDF, 475 KB

english, 1981

26

Role of superoxide in the N-oxidation of N-(2-methyl-1-phenyl-2-propyl)hydroxylamine by the rat liver cytochrome P-450 system

Duncan, John D., Di Stefano, Emma W., Miwa, Gerald T., Cho, Arthur K.

Journal:

Year:

1985

Language:

english

File:

PDF, 922 KB

english, 1985

27

Oxidative Deboronation of the Peptide Boronic Acid Proteasome Inhibitor Bortezomib: Contributions from Reactive Oxygen Species in This Novel Cytochrome P450 Reaction

Labutti, Jason, Parsons, Ian, Huang, Ron, Miwa, Gerald, Gan, Liang-Shang, Daniels, J. Scott

Journal:

Chemical Research in Toxicology

Year:

2006

Language:

english

File:

PDF, 390 KB

english, 2006

28

A simple and rapid procedure for the purification of phenobarbitalinducible cytochrome P-450 from rat liver microsomes

Susan B. West, Mou-Tuan Huang, Gerald T. Miwa, Anthony Y.H. Lu

Journal:

Archives of Biochemistry and Biophysics

Year:

1979

Language:

english

File:

PDF, 2.34 MB

english, 1979

29

Mechanism of reductive activation of a 5-nitroimidazole by flavoproteins: Model studies with dithionite

Gregory L. Kedderis, Lois S. Argenbright, Gerald T. Miwa

Journal:

Archives of Biochemistry and Biophysics

Year:

1988

Language:

english

File:

PDF, 761 KB

english, 1988

30

Structural alterations that differentially affect the mutagenic and antitrichomonal activities of 5-nitroimidazoles

Walsh, John S., Wang, Regina, Bagan, Edward, Wang, C. C., Wislocki, Peter, Miwa, Gerald T.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 1.02 MB

english, 1987

31

[Part 1: Biological Sciences] || N-acetyl-p-benzoquinone Imine: A Cytochrome P-450-Mediated Oxidation Product of Acetaminophen

David C. Dahlin, Gerald T. Miwa, Anthony Y. H. Lu and Sidney D. Nelson

Journal:

Proceedings of the National Academy of Sciences

Year:

1984

Language:

english

File:

PDF, 848 KB

english, 1984

32

The direct oxidation of ethanol by a catalase- and alcohol dehydrogenase-free reconstituted system containing cytochrome P-450

Gerald T. Miwa, Wayne Levin, Paul E. Thomas, Anthony Y.H. Lu

Journal:

Archives of Biochemistry and Biophysics

Year:

1978

Language:

english

File:

PDF, 1.08 MB

english, 1978

33

Bis(monoacylglycerol)phosphate as a non-invasive biomarker to monitor the onset and time-course of phospholipidosis with drug-induced toxicities

Tengstrand, Elizabeth A, Miwa, Gerald T, Hsieh, Frank Y

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2010

Language:

english

File:

PDF, 616 KB

english, 2010

34

Determination of drug plasma protein binding by solid phase microextraction

Florin Marcel Musteata, Janusz Pawliszyn, Mark G. Qian, Jing-Tao Wu, Gerald T. Miwa

Journal:

Journal of Pharmaceutical Sciences

Year:

2006

Language:

english

File:

PDF, 188 KB

english, 2006

35

Species-Specific, P450- and Sulfotransferase-Mediated Novel Ring Contraction of a Naphthyridine- N -Oxide Compound in Cynomolgus Monkey †

Daniels, J. Scott, Espina, Robert, Cao, Kevin, Yuan, Haodan, Lin, Jianrong, Diamond, Sharon, Johnson, Barry, Rodgers, James, Prakash, Shimoga, Unger, Steve, Christ, David, Miwa, Gerald, Gan, Liang-Sha

Journal:

Chemical Research in Toxicology

Year:

2007

Language:

english

File:

PDF, 196 KB

english, 2007

36

Drug residue formation from ronidazole, a 5-nitroimidazole. VII. Comparison of protein-bound products formed in vitro and in vivo

Gerald T. Miwa, Raul F. Alvaro, John S. Walsh, Regina Wang, Anthony Y.H. Lu

Journal:

Chemico-Biological Interactions

Year:

1984

Language:

english

File:

PDF, 781 KB

english, 1984

37

Kinetic isotope effects on cytochrome P-450-catalyzed oxidation reactions: Full expression of the intrinsic isotope effect during the O-deethylation of 7-ethoxycoumarin by liver microsomes from 3-methylcholanthrene-induced hamsters

Gerald T. Miwa, Nobuhiro Harada, Anthony Y.H. Lu

Journal:

Archives of Biochemistry and Biophysics

Year:

1985

Language:

english

File:

PDF, 679 KB

english, 1985

38

Toxicological Protein Biomarker Analysis—An Investigative One-week Single Dose Intravenous Infusion Toxicity and Toxicokinetic Study in Cynomolgus Monkeys using an Antibody–cytotoxic Conjugate against Ovarian Cancer

Frank Y. Hsieh, Elizabeth Tengstrand, Lily Y. Li, Yuling N. Huang, Mark N. Milton, Lee Silverman, Carl Alden, Gerald Miwa, Frank Lee

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 901 KB

english, 2008

39

The mechanism of the cytochrome P-448 mediated 6-hydroxylation of 7-ethoxycoumarin

John S. Walsh, Gerald T. Miwa

Journal:

Biochemical and Biophysical Research Communications

Year:

1984

Language:

english

File:

PDF, 295 KB

english, 1984

40

In vitro studies on the interaction of famotidine with liver microsomal cytochrome P-450

Regina W. Wang, Gerald T. Miwa, Lois S. Argenbright, Anthony Y.H. Lu

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 401 KB

english, 1988

41

Stimulation of microsomal N-demethylation by solubilized NADPH-cytochrome c reductase

Gerald T. Miwa, Arthur K. Cho

Journal:

Year:

1976

Language:

english

File:

PDF, 294 KB

english, 1976

42

[Annual Reports in Medicinal Chemistry] Volume 13 || Chapter 22. Molecular Aspects of Drug Metabolism

Miwa, Gerald T.

Year:

1978

Language:

english

File:

PDF, 871 KB

english, 1978

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